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Subscribe to this list via RSS Blog posts tagged in inflammation
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BACKGROUND
b2ap3_thumbnail_Abdominal-Pain-Is-It-Appendicitis_article_main.jpgI first met Todd* with his wife in October 2016. He had been diagnosed with Crohn's disease (an autoimmune inflammatory bowel disorder) three years prior.  His symptoms included abdominal pain and loose stools with blood and mucous.

During our first visit, I learned that during the time his symptoms began Todd had been under increased stress with an upcoming wedding, a change in employment, and home renovations.

He had originally been treated with sulfasalazine, a common prescription medication for Crohn's, however, the medication made him nauseated and his symptoms were not well controlled. He had been unable to increase the dose as recommended due to side effects.

Todd continued to have frequent loose bowel movements within 15 minutes of eating, often associated with mucus and blood. He was experiencing sharp localized abdominal pain with activity, and the pain was limiting his ability to perform his physically strenuous job as an electrical lineman.

Prior to our first visit, Todd and his wife had already explored holistic options for his treatment. He had tried digestive enzymes, probiotics, and homeopathic remedies without relief. He had also completed a two month trial of a gluten-free diet but was unsure if that made any difference.


INITIAL WORK UP
At our first visit, I ordered a comprehensive laboratory evaluation to screen for:
  • Inflammation
  • Nutritional deficiencies
  • Anemia
  • Hormone balance
  • Candida/Yeast
  • Celiac disease
I also ordered Functional Stool Testing.

While waiting for results, I recommended that Todd begin a four-week Comprehensive Elimination Diet, and provided educational materials and book recommendations for support with this.

Blood testing revealed low levels of zinc, and significant vitamin D deficiency, but was otherwise normal. Functional stool testing indicated significant intestinal inflammation and low levels of "good" gut bacteria.

Recommendations were customized for Todd based on his laboratory results (no more “guessing game” when it comes to supplements):
  • Vitamin D (which supports the immune system response)
  • Zinc carnosine (a key factor in the health of the intestinal lining)
  • Fish Oil (a natural anti-inflammatory)
  • Immunoglobulin powder (derived from colostrum)
  • VSL#3 - A high-dose prescription-grade probiotic (this brand has solid evidence supporting its use in the treatment of Crohn’s)
I also prescribed Low-Dose Naltrexone (LDN), an opioid antagonist that has an outstanding safety profile and has shown promise in the treatment of Crohn’s in both adults and children with minimal side effects.


TWO MONTHS LATER–IMPROVEMENT!
Two months after initiating diet changes, LDN and targeted supplementation, Todd reported his pain improved by at least 50% with some pain-free days and improved energy. While still experiencing blood in his stools, he described it as much less than before.

I recommended he add a glutamine/aloe combination to promote further healing of the intestinal lining.


SIX MONTHS LATER–MORE IMPROVEMENT!
b2ap3_thumbnail_intestines.jpgAt six months Todd reported that he continued to experience significant improvement and was very pleased with his progress. He described his pain as minimal, with only minor flares "nothing like it was before”. He had good energy and stamina and was no longer having any work pain. He had become a “believer” in his regimen of supplements and LDN, having forgotten them on two nights, each time with a symptom flare.

While bowel movements had earlier been improved, he had since noticed increased blood and mucus in his stools, so a low dose of Sulfasalazine had been restarted.

He continued to cautiously experiment with his diet, determining his “trigger foods”.


ONE YEAR LATER
This past fall I was able to meet with Todd and his wife for his one-year follow-up. He reported great energy and stamina, no work pain, and no blood in his stools.

While still on the low dose of Sulfasalazine, it was a dose that did not give him side effects and his symptoms as a whole were nearly resolved. Follow up laboratory testing showed normalized levels of iron, zinc and Vitamin D.

I ordered comprehensive nutritional testing at this visit, which allowed us to customize Todd’s diet and supplement needs. His testing showed a need for B-vitamins, as well as magnesium and enhanced antioxidant support to reduce oxidative stress in the intestinal lining. Based on this testing, I also recommended he begin to reduce the amount of animal protein in his diet, transitioning to plant-based proteins.

In just one year, Todd was able to get much better control of his Crohn’s disease through changes in diet, targeted supplementation, and lower-doses of prescription medications without side effects. He had normalized bowel movements, no blood in his stool, minimal pain and improved energy. I look forward to continuing to work with Todd and his wife to optimize his nutrition, simplify his regimen as he continues to heal, and achieve further success!

*Patient names are changed to protect privacy

Carin Nielsen, MD Integrative Medicine I use an Integrative/Functional Medicine approach with my patients to treat a variety of chronic medical conditions, including many autoimmune conditions. Treating symptoms simply by prescribing medication as a “band-aid” does not address the underlying factors that contributed your problems in the first place, and is not likely to provide lasting results. My approach involves getting "under the surface” (using assessments like estrogen metabolite testing) to find and correct underlying imbalances. If you are interested in learning more or if you would like to schedule a consultation, please contact our office This email address is being protected from spambots. You need JavaScript enabled to view it. or 231-638-5585.
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646
b2ap3_thumbnail_HealingArthritis.jpgIn Healing Arthritis, Dr. Susan Blum, author of the bestselling The Immune System Recovery Plan shares her science-based, drug-free treatment plan for the almost fifty million people who suffer from arthritis.

FROM THE PUBLISHER:
Arthritis is the most common cause of disability in the world—greater than both back pain and heart disease. One example, Rheumatoid Arthritis (RA), is the most common autoimmune disease, affecting 1% of the US population, and almost 68 million people worldwide. Conventional medicine tends to treat arthritis with strong, gut-damaging, immune-suppressing pain medications, temporarily relieving the symptoms of the disease without addressing its root causes. Now, in her groundbreaking new book, Dr. Susan Blum, a leading expert in functional medicine, offers a better approach to healing arthritis permanently.

MY THOUGHTS:
This book is a must-read for anyone suffering from joint pain or arthritis. While I’ve been recommending Dr. Blum’s first book The Immune System Recovery Plan to my patients for years, I find Healing Arthritis easier to read and more user-friendly for my patients to navigate. The book provides an overview of the root causes of inflammation/arthritis, focusing on:
  • inflammatory foods
  • gut health
  • the role of stress/trauma
Dr. Blum includes a straightforward two-week plan to quickly reduce pain through anti-inflammatory foods and supplements; followed by an intensive gut repair program. Once through this initial phase, her plan addresses the emotional issues that contribute to inflammation and outlines a simple, Mediterranean inspired diet to maintain a healthy gut.

I was pleased to see that the diet and supplement recommendations are given are the same available to patients in my office! This book will serve as a useful companion for patients navigating the world of Functional Medicine in treating arthritis and controlling inflammation.

Carin Nielsen, MD Integrative Medicine I use an Integrative/Functional Medicine approach with my patients to treat a variety of chronic medical conditions, including arthritis. Treating symptoms simply by prescribing medication as a “band-aid” does not address the underlying factors that contributed your problems in the first place, and is not likely to provide lasting results. When treating arthritis and autoimmune disease, my approach involves treating root causes such as toxicity, food allergy/sensitivity, stress/trauma and underlying infection. If you are interested in learning more or if you would like to schedule a consultation, please contact our office This email address is being protected from spambots. You need JavaScript enabled to view it. or 231-638-5585.
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1815

Leaky Gut = Inflammation, Food Sensitivities, Nutrient Deficiencies and Autoimmune Disease

b2ap3_thumbnail_GutHealing.jpgOur intestinal lining is a very important barrier. When working properly, the lining allows only certain small desirable substances (like nutrients) to pass through, while keeping out larger undesirable particles (like infections, allergens and toxins).

Think of your intestinal lining like a net with very small holes. If the net becomes damaged and the holes of the net become larger, then larger particles are able to pass through the net that ordinarily couldn’t. This damaged intestinal lining is what may lead to increased intestinal permeability, or “leaky gut”.

b2ap3_thumbnail_FineMeshStrainer.jpgIf the intestinal lining is damaged or compromised, undesirable substances such as bacteria, viruses, undigested food particles and toxic waste products can leak from the inside of your intestines through the damaged lining into your bloodstream. Once they get into your bloodstream, these particles are transported throughout your body and can trigger your immune system to react. The end result is inflammation in various parts of your body.


An unhealthy intestinal lining can be a major source of inflammation in your body.

The inflammation in your body caused by a damaged digestive lining can lead to a wide variety of symptoms, including:
  • Bloating and abdominal cramps 
  • Fatigue and “brain fog” 
  • Rashes, Eczema and Acne 
  • Food sensitivities 
  • Weight Gain 
  • Joint pain 
  • Headaches 
  • Depression and Mood Swings 
  • Chronic sinus infections 
  • Allergies 

When your intestinal lining is unhealthy, you are more likely to have food sensitivities.

When you have a leaky gut, certain foods that you eat are likely to make your symptoms worse. This is because large, undigested food particles entering the bloodstream trigger your immune system to react, promoting more inflammation and symptoms such as listed above.


An unhealthy intestinal lining can also lead to nutrient deficiencies.

With leaky gut not only is the intestinal lining more porous (bigger holes in the net) and less selective about what can get in, but normal absorption can also be affected. Intestinal villi are finger-like projections in the wall of the small intestine that are responsible for absorbing nutrients. When these villi become damaged, certain nutrients are not able to be properly absorbed, resulting in nutrient deficiencies. Common deficiencies seen include:
  • Iron 
  • Vitamin B12 
  • Magnesium 
  • Zinc 

An unhealthy intestinal lining over time can lead to autoimmune disorders.

There is a growing consensus that the immune system response triggered by leaky gut may be a primary cause of autoimmune disease. As discussed above, your immune system acts like your own personal army, ready for attack! When larger, undesirable particles get into the bloodstream, the immune system goes on “high alert”, increasing inflammation in preparation of fighting off invaders. The immune system then may begin to produce antibodies to attack and destroy these invaders. Problems result when this antibody response gets out of control, and begins to attack your own tissues. This is self-attack-self, the hallmark of autoimmune disease. This may trigger or worsen conditions such as:
  • Rheumatoid Arthritis 
  • Thyroid disorders 
  • Psoriasis 
  • Celiac disease 
Before you jump to potentially harmful prescription medication - get to the root of the problem! Healing an unhealthy intestinal lining is one of the most important steps in treating a variety of symptoms and conditions, including autoimmune disease.



Carin Nielsen, MD Integrative MedicineI use an Integrative/Functional Medicine approach with my patients to treat a variety of chronic medical conditions, including many that are linked to an unhealthy digestive lining. Treating symptoms simply by prescribing medication as a “band-aid" doesn't address the underlying factors that contributed your problems in the first place, and is not likely to provide lasting results. My approach involves getting "under the surface" to find and correct underlying imbalances. If you are interested in learning more or if you would like to schedule a consultation, please contact our office This email address is being protected from spambots. You need JavaScript enabled to view it. or 231-638-5585.


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1829
b2ap3_thumbnail_fire.jpgIt is well established that chronic inflammation is a key factor in most chronic disease, yet many doctors overlook the one simple blood test that can assess your level of inflammation. Often without symptoms, chronic, low-level inflammation may be threatening your health right now without you even knowing it!



Inflammation - the Good and the Bad

Inflammation in your body has a purpose - to treat injury and illness. Without inflammation, wounds would not heal and simple infections could become deadly. The inflammation in your body that treats injury and illness comes from your immune system. Think of your immune system like your own personal army, ready for attack. If you become ill or injured, your immune system activates pathways of inflammation in your body for healing. You can see and feel this inflammation as swelling, pain, warmth and redness at an injury site or warmth from a developing fever. These symptoms are all signs that your immune system is doing it’s job! When your immune system is working properly, the inflammation is temporary, and the inflammatory pathways in your body are turned off as you heal.

b2ap3_thumbnail_injury.jpgWhile temporary, purposeful inflammation is healthy, too much inflammation in the body is not. When inflammation persists or serves no purpose, it damages the body and causes illness. In the brains of Alzheimer’s patients, inflammation destroys nerve cells. Inside arteries, smoldering inflammation damages the arterial lining and helps kick off atherosclerosis (plaque). Inside joints, inflammation eats away at cartilage causing painful arthritis.


It is well-established that chronic inflammation is the root cause of many chronic diseases, including:

  • Heart disease
  • Stroke
  • Obesity
  • Many cancers
  • Arthritis
  • Alzheimer's disease
  • Diabetes

Causes of chronic inflammation:

  • b2ap3_thumbnail_Donuts.jpgStress 
  • Lack of exercise 
  • Genetic predisposition
  • Elevated blood sugars
  • Excessive calorie consumption
  • Excessive body fat (fat cells release inflammatory signals in the body)
  • Exposure to toxins (cigarettes, pesticides, heavy metals, etc.)
  • Periodontal disease
  • Infection and Imbalance in the Digestive Tract
  • Inflammatory foods 


Testing for Inflammation

Knowing your level of underlying inflammation can be a key step in making changes to reduce the development of many chronic diseases and avoid age-related health decline.

hsCRP = high-sensitivity C-reactive protein

There are several tests that can be used to assess your level of inflammation, but the one test you need to start with is the high-sensitivity C-reactive protein, or hsCRP. C-reactive protein (CRP) is a substance produced by the liver that increases in the presence of inflammation in the body. Elevated levels indicate inflammation due to infection or tissue injury. The high-sensitivity type of this test can detect chronic inflammation even at very low levels.

Do you know your hsCRP value and what it means?

hsCRP value of 2.0 or greater is considered high risk

hsCRP value 1.0-1.9 is considered borderline risk

hsCRP value kess than 1.0 is desired


If you are interested in knowing your hsCRP value, you can order a hsCRP laboratory test directly through my website without an appointment!  Follow this link to avoid insurance hassles with affordable testing and get fast results!



Carin Nielsen, MD Integrative MedicineLooking for a personalized approach to your healthcare? I use an Integrative/Functional Medicine approach with my patients to treat a variety of chronic medical conditions. Treating symptoms and chronic disease simply by prescribing medication doesn't address the underlying factors that contributed your problems in the first place, and is not likely to provide lasting results. My approach involves getting "under the surface" to find and correct underlying imbalances. If you are interested in learning more or if you would like to schedule a consultation, please contact our office This email address is being protected from spambots. You need JavaScript enabled to view it. or 231-638-5585.


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