5 Must-Have Supplements for GLP-1 Users
If you’re using a medication like semaglutide or tirzepatide to help with weight loss, you’re likely noticing how effective they are at curbing appetite and balancing blood sugar. While these medications can be highly effective for weight loss, they also change the way your body handles food and nutrients, which can sometimes lead to nutritional gaps.
To ensure you feel your best and avoid unintended side effects like fatigue, muscle loss, hair thinning, or digestive discomfort, certain supplements can be game-changers. Here are the five key supplements I recommend for anyone using a GLP-1 agonist for weight loss.
5 Supplements for Those Using a GLP-1 Agonist for Weight Loss
1. A Quality Multivitamin
When you're eating less, you may not be meeting all your nutritional needs. A high-quality multivitamin ensures your body is getting essential vitamins and minerals to keep your energy levels steady, support immune function, and promote overall health.
What to look for: Choose a multivitamin with bioavailable forms of nutrients - like methylated B vitamins and chelated minerals - for better absorption. You may find it easier to digest a capsule vs a tablet form.
Why it’s important: Nutrient deficiencies can creep up when your caloric intake is reduced. A multivitamin acts as nutritional insurance.
2. All-in-One Protein Shake Mix
Protein is VITAL for preserving muscle mass while losing weight. Unfortunately, with a reduced appetite, getting enough protein can be a challenge. An all-in-one protein shake mix simplifies this by providing a convenient, nutrient-rich way to meet your protein needs.
What to look for: Look for a protein shake mix with at least 15-25 grams of high-quality protein per serving, along with added fiber and less than 5 net carbs. Whey protein and vegan pea/rice blends are my favorite.
Why it’s important: Protein helps maintain lean muscle, supports metabolism, and keeps you feeling fuller longer—key benefits when you're losing weight.
3. Collagen Protein Powder
Collagen is the most abundant protein in your body, supporting skin elasticity, bone and joint health, and strong hair and nails. Collagen protein powder is a great addition to your protein shake to get you to the 30g protein threshold!
What to look for: Opt for a hydrolyzed collagen powder (also called collagen peptides) for better absorption. Look for powders sourced from grass-fed or wild-caught sources.
Why it’s important: Many people on GLP-1 agonists report hair thinning due to reduced nutrient intake. In addition to muscle and bone benefits, collagen provides the building blocks for hair, skin, and nails, keeping them strong and vibrant.
4. Digestive Enzymes
One common side effect of GLP-1 agonists is digestive discomfort, such as bloating, nausea, or a feeling of fullness even after eating smaller portions. Adding digestive enzymes may ease these symptoms by helping your body break down food more efficiently.
What to look for: Choose a comprehensive digestive enzyme formula that includes proteases (for proteins), lipases (for fats), and amylases (for carbohydrates).
Why it’s important: Digestive enzymes can reduce feelings of discomfort, improve nutrient absorption, and make mealtimes more enjoyable—even with a smaller appetite.
5. Fiber
GLP-1 agonists slow gastric emptying, which can sometimes lead to constipation. Adding a fiber supplement to your routine helps keep things moving. Fiber also supports gut health by feeding the “good bugs” in your gut.
What to look for: Psyllium husk is a great option for bulk-forming fiber, while prebiotic fibers like Sunfiber® can nourish your gut microbiome. With all fiber supplements, start low and go slow to avoid bloating.
Why it’s important: Adequate fiber is essential for regular bowel movements, balancing blood sugar, and feeding the beneficial bacteria in your gut.
Practical Tips for Success
Start Small: Introduce supplements one at a time to monitor how your body responds.
Stay Consistent: Consistency is key to seeing benefits, so find a time of day that works for you.
Focus on Whole Foods Too: While these supplements are helpful, remember to eat a balanced diet rich in whole, nutrient-dense foods when possible.
As always, consult with your healthcare provider before starting any new supplement regimen to ensure it’s right for your unique needs.
Are you ready to supercharge your health and wellness journey? I can help! As a board-certified Integrative & Functional Medicine physician, I can help you “think outside of the box and dig deeper with a variety of laboratory testing to help uncover the underlying root causes of your symptoms and create a plan personalized for you that goes beyond the prescription pad to incorporate diet/lifestyle change, nutritional supplements, holistic therapies, health coaching and more! Contact us to get started!